The genetic landscape of autism spectrum disorders
نویسندگان
چکیده
منابع مشابه
The genetic landscapes of autism spectrum disorders.
The autism spectrum disorders (ASD) are characterized by impairments in social interaction and stereotyped behaviors. For the majority of individuals with ASD, the causes of the disorder remain unknown; however, in up to 25% of cases, a genetic cause can be identified. Chromosomal rearrangements as well as rare and de novo copy-number variants are present in ∼10-20% of individuals with ASD, com...
متن کاملGenetic Heterogeneity of Autism Spectrum Disorders
Although autism is considered to be one of the most highly heritable psychiatric disorders, molecular mechanisms underlying its pathogenesis remain largely unresolved. A strong genetic component underlying autism spectrum disorders (ASD) has been firmly established from various lines of studies ranging from whole genome scans to genetic association studies. Recent genomic advances have led to s...
متن کاملClinical Genetic Aspects of Autism Spectrum Disorders
Early presumptions opined that autism spectrum disorder (ASD) was related to the rearing of these children by emotionally-distant mothers. Advances in the 1960s and 1970s clearly demonstrated the biologic basis of autism with a high heritability. Recent advances have demonstrated that specific etiologic factors in autism spectrum disorders can be identified in 30%–40% of cases. Based on early r...
متن کاملGenetic testing for autism spectrum disorders.
Children with autism spectrum disorders (ASD) have unique developmental and behavioral phenotypes, and they have specific challenges with communication, social skills, and repetitive behaviors. At this time, no single etiology for ASD has been identified. However, evidence from family studies and linkage analyses suggests that genetic factors play a pivotal role in the etiology of ASD. However,...
متن کاملGenetic research in autism spectrum disorders
PURPOSE OF REVIEW The recent explosion of genetic findings in autism spectrum disorder (ASD) research has improved knowledge of the disorder's underlying biology and etiologic architecture. This review introduces concepts and results from recent genetic studies and discusses the manner in which those findings can influence the trajectory of ASD research. RECENT FINDINGS Large consortium studi...
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ژورنال
عنوان ژورنال: Developmental Medicine & Child Neurology
سال: 2013
ISSN: 0012-1622
DOI: 10.1111/dmcn.12278